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Scientists in Anhui Find New Therapy for Small Cell Lung Cancer

Pub Date:17-07-18 10:26 Source:www.cnanhui.org

Scientists in Hefei, capital of East China’s Anhui province, have found an effective therapy that could keep small-cell lung cancer (SCLC) in check.

A team led by Lin Wenchu, a researcher with the Hefei Institutes of Physical Science, Chinese Academy of Sciences, said in a paper that combination of RAD0001 and BEZ235, two small-molecule inhibitors, may serve as an effective regimen for SCLC treatment.

The article was published in the online version of an international academic journal.

By mining the Cancer Cell Line Encyclopedia (CCLE) database, the team found that combination of RAD0001 and BEZ235 synergistically inhibited the growth of SCLC cells, which was accompanied by enhanced induction of cell cycle arrest and apoptosis.

SCLC is a highly malignant cancer with few targeted therapies. It accounts for 15-20 percent of lung cancers.


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